neurobiology of the gut-brain-axis

horn lab



Nanivadekar AC, Miller DM, Fulton S, Wong L, Ogren J, Chitnis G, McLaughlin B, Zhai S, Fisher LE, Yates BJ, Horn CC. Machine learning prediction of emesis and gastrointestinal state in ferrets. PLoS One. 2019 Oct 18;14(10):e0223279. doi: 10.1371/journal.pone.0223279. eCollection 2019. PubMed PMID: 31626659; PubMed Central PMCID: PMC6799899.

Horn CC, Ardell JL, Fisher LE. Electroceutical Targeting of the Autonomic Nervous System. Physiology (Bethesda). 2019 Mar 1;34(2):150-162. doi: 10.1152/physiol.00030.2018. PubMed PMID: 30724129; PubMed Central PMCID: PMC6586833.

Javid FA, Afshin-Javid S, Horn CC. Further investigation of the effects of 5-hydroxytryptamine, 8-OH-DPAT and DOI to mediate contraction and relaxation responses in the intestine and emesis in Suncus murinus. Eur J Pharmacol. 2018 Feb 15;821:79-87. doi: 10.1016/j.ejphar.2017.12.051. Epub 2017 Dec 23. PubMed PMID: 29277716.

Eiseman JL, Sciullo M, Wang H, Beumer JH, Horn CC. Estimation of body surface area in the musk shrew ( Suncus murinus): a small animal for testing chemotherapy-induced emesis. Lab Anim. 2017 Oct;51(5):534-537. doi: 10.1177/0023677217695851. Epub 2017 Feb 26. PubMed PMID: 28948895; PubMed Central PMCID: PMC5654602.

Lothet EH, Shaw KM, Lu H, Zhuo J, Wang YT, Gu S, Stolz DB, Jansen ED, Horn CC, Chiel HJ, Jenkins MW. Selective inhibition of small-diameter axons using infrared light. Sci Rep. 2017 Jun 12;7(1):3275. doi: 10.1038/s41598-017-03374-9. PubMed PMID: 28607402; PubMed Central PMCID: PMC5468240.

Eiseman JL, Sciullo M, Wang H, Beumer JH, Horn CC. Estimation of body surface area in the musk shrew ( Suncus murinus): a small animal for testing chemotherapy-induced emesis. Lab Anim. 2017 Oct;51(5):534-537. doi: 10.1177/0023677217695851. Epub 2017 Feb 26. PubMed PMID: 28948895; PubMed Central PMCID: PMC5654602.

Horn CC, Yates BJ. Biology and control of nausea and vomiting 2015: Perspectives and overview of the conference. Auton Neurosci. 2017 Jan;202:3-4. doi: 10.1016/j.autneu.2016.10.002. Epub 2016 Oct 19. PubMed PMID: 27773432.

De Jonghe BC, Horn CC. The importance of systematic approaches in the study of emesis. Temperature (Austin). 2015 Oct 12;2(3):322-3. doi: 10.1080/23328940.2015.1066924. eCollection 2015 Jul-Sep. PubMed PMID: 27227036; PubMed Central PMCID: PMC4843914.

Gupta RG, Schafer C, Ramaroson Y, Sciullo MG, Horn CC. Role of the abdominal vagus and hindbrain in inhalational anesthesia-induced vomiting. Auton Neurosci. 2017 Jan;202:114-121. doi: 10.1016/j.autneu.2016.06.007. Epub 2016 Jul 2. PubMed PMID: 27396693; PubMed Central PMCID: PMC5203944.

Rosenberg DM, Horn CC. Neurophysiological analytics for all! Free open-source software tools for documenting, analyzing, visualizing, and sharing using electronic notebooks. J Neurophysiol. 2016 Aug 1;116(2):252-62. doi: 10.1152/jn.00137.2016. Epub 2016 Apr 20. PubMed PMID: 27098025; PubMed Central PMCID: PMC4969392.

Horn CC, Zirpel L, Sciullo M, and Rosenberg D. Impact of electrical stimulation of the stomach on gastric distension-induced emesis in the musk shrew. Neurogastroenterology and Motility, 2016 (in press).

Donovan HS, Hagan TL, Campbell GB, Boisen MM, Rosenblum LM, Edwards RP, Bovbjerg DH, Horn CC. Nausea as a sentinel symptom for cytotoxic chemotherapy effects on the gut-brain axis among women receiving treatment for recurrent ovarian cancer: an exploratory analysis. Support Care Cancer. 2016 Jan 8. [Epub ahead of print] PubMed PMID: 26746209.

Eiseman J, Beumer J, Rigatti L, Strychor S, Meyers K, Dienel S, Horn CC. Plasma pharmacokinetics and tissue and brain distribution of cisplatin in musk shrews. Cancer Chemotherapy and Pharmacology. 2014; 75(1):143-52.

Horn CC. The medical implications of gastrointestinal vagal afferent pathways in nausea and vomiting. Current Pharmaceutical Design. 2014;20(16):2703-12.

Horn, CC, Yates, BJ. “Biology and Control of Nausea and Vomiting: Outcomes of the 2013 University of Pittsburgh Conference.” Experimental Brain Research, 2014. doi:10.1007/s00221-014-4026-6.

Horn CC, Meyers K, Lim A, Dye M, Pak D, Rinaman L, Yates BJ. Delineation of vagal emetic pathways: Intragastric copper sulfate-induced emesis and viral tract tracing in musk shrews. Am J Physiol (Reg Comp Integr Physiol), 2014, 306:R341-R351.

Horn CC, Wallisch WJ, Homanics GE, Williams JP. Pathophysiological and neurochemical mechanisms of postoperative nausea and vomiting. European Journal of Pharmacology 2014; 722:55-66.

Horn CC, Meyers K, Oberlies N. Musk shrews selectively bred for motion sickness display increased anesthesia-induced vomiting. Physiology and Behavior, 2014, 124:129-137.

Horn CC. Measuring the nausea-to-emesis continuum in non-human animals: Refocusing on gastrointestinal vagal signaling. Experimental Brain Research 2014; 232 (8):2471-81.

Horn CC. Overlapping phenotypes: Genetic contribution to nausea and pain. In “Genetics of Human Pain Perception,” Edited by Inna Belfer and Luda Diatchenko. John Wiley & Sons, Inc. (Dec. 2013)

Horn CC, Wang H, Estival L, Meyers K, Magnusson M. Novel dynamic measures of emetic behavior in musk shrews. Autonomic Neuroscience: Basic and Clinical, 2013, 179:60-67.

Horn CC, Kimball BA, Wang H, Kaus J, Dienel S, Nagy A, Gathright GR, Yates BJ, Andrews PLR. Why can’t rodents vomit? A comparative behavioral, anatomical, and physiological study. PLOS ONE, 2013, 10;8(4):e60537.

Horn CC, Meyers K, Pak D, Nagy A, Apfel CC, Williams BA. Post-anesthesia vomiting: Impact of isoflurane and morphine on ferrets and musk shrews. Physiology and Behavior, 2012, 106:562-8.

Horn CC, Murat C, Rosazza M, Still L. Effects of gastric distension and infusion of umami and bitter taste stimuli on vagal afferent activity. Brain Research. 2011, 1419:53-60.

Horn CC, Henry S, Meyers K, Magnusson MS. Behavioral patterns associated with chemotherapy-induced emesis: A potential signature for nausea in musk shrews. Frontiers in Neuroscience. 2011. 5:88.

Huang D, Meyers K, Henry S, De la Torre F, Horn CC. Computerized detection and analysis of cancer chemotherapy-induced vomiting in a small animal model, musk shrew. Journal of Neuroscience Methods. 2011. 197:249-58.

Horn CC, Still L, Fitzgerald C, Friedman MI. Food restriction, refeeding, and gastric fill fail to affect emesis in musk shrews. Am J Physiol (Gastrointest Liver Physiol). 2010, 298: G25-30.

Horn CC, De Jonghe BC, Matyas K, Norgren R. Chemotherapy-induced kaolin intake is increased by lesion of the lateral parabrachial nucleus of the rat. Am J Physiol (Reg Comp Integr Physiol). 2009, 297:R1375-82.

Horn CC. Brain Fos expression induced by the chemotherapy agent cisplatin in the rat is partially dependent on an intact vagus. Auton Neurosci. 2009, 148(1-2):76-82.

De Jonghe BC, Horn CC. Chemotherapy agent cisplatin induces 48 h Fos expression in the brain of a vomiting species, the house musk shrew (Suncus murinus). Am J Physiol (Reg Comp Integr Physiol). 2009, 296(4):R902-11.

Horn CC. Electrophysiology of vagal afferents: Amino acid detection in the gut. Ann N Y Acad Sci. 2009; 1170:69-76.

De Jonghe BC, Lawler MP, Horn CC, Tordoff MG. Pica as an adaptive response: Kaolin consumption helps rats recover from chemotherapy-induced illness. Physiology and Behavior, 2009, 97(1), 87-90.

Horn CC. Why is the neurobiology of nausea and vomiting so important? Appetite. 2008; 50:430-4.

De Jonghe BC, Horn CC. Chemotherapy-induced pica and anorexia are reduced by common hepatic branch vagotomy in the rat. Am J Physiol (Reg Comp Integr Physiol). 2008 294(3):R756-65.

Horn CC. Is there a need to identify new anti-emetic drugs? Drug Discovery Today: Therapeutic Strategies. Drug Discov Today Ther Strateg. 2007;4(3):183-187.

Garcia-Medina NE, Jimenez-Capdeville ME, Ciucci M, Martinez LM, Delgado JM, Horn CC. Conditioned Flavor Aversion and Brain Fos Expression Following Exposure to Arsenic. Toxicology. 2007, 235:73-82.

Jing J, Vilim FS, Horn CC, Alexeeva V, Hatcher NG, Sasaki K, Yashina I, Zhurov Y, Kupfermann I, Sweedler JV, Weiss KR. From Hunger to Satiety: Reconfiguration of a Feeding Network by Aplysia Neuropeptide Y. J Neurosci. 2007, 27:3490-502.

Horn CC, Ciucci M, Chaudhury A. Brain Fos expression during 48 h after cisplatin treatment: Neural pathways for acute and delayed visceral sickness. Auton Neurosci. 2007, 132:44-51.

Andrews PLR, Horn CC. Signals for nausea and emesis: Implications for models of upper gastrointestinal diseases. Auton Neurosci. 2006, 125:100-115.

Horn CC, Friedman MI. Thoracic cross-over pathways of the rat vagal trunks. Brain Res. 2005, 1060:153-161.

Friedman MI, Horn CC, Ji H. Peripheral signals in the control of feeding behavior. Chem Senses. 2005, 30:i182-i183.

Brezina V, Horn CC, Weiss KR. Modeling neuromuscular modulation in Aplysia. III. Interaction of central motor commands and peripheral modulatory state for optimal behavior. J Neurophysiol. 2005, 93:1523-1556.

Horn CC, Richardson EJ, Andrews PLR, Friedman MI. Differential effects on gastrointestinal and hepatic vagal afferent fibers in the rat by the anti-cancer agent cisplatin. Auton Neurosci. 2004, 115:74-81.

Horn CC, Friedman MI. Separation of Hepatic and Gastrointestinal Signals from the Common "Hepatic" Branch of the Vagus. Am J Physiol (Reg Comp Integr Physiol). 2004, 287:R120-R126.

Horn CC, Zhurov Y, Orekhova IV, Proekt A, Kupfermann I, Weiss KR, Brezina V. Cycle-to-cycle variability of neuromuscular activity in Aplysia feeding behavior. J Neurophysiol. 2004, 92:157-180.

Horn CC, Ji H, Friedman MI. Etomoxir, a fatty acid oxidation inhibitor, increases food intake and reduced hepatic energy status in rats. Physiol Behav. 2004, 81:157-162.

Horn CC, Friedman MI. Detection of single unit activity from the rat vagus using cluster analysis of principal components. J Neurosci Meth. 2003, 122:141-147.

Horn CC, Kupfermann I. Egestive feeding responses in Aplysia persist after sectioning of the cerebral-buccal connectives: Evidence for multiple sites of control of motor programs. Neurosci Lett. 2002, 323:175-178.

Horn CC, Geizhals CR, Kupfermann I. Further studies of bulk and orosensory decrement in producing satiation of feeding in Aplysia. Brain Res. 2001, 918:51-59.

Horn CC, Tordoff MG, Friedman MI. Role of vagal afferent innervation in feeding and brain Fos expression produced by metabolic inhibitors. Brain Res. 2001, 919:198-206.

Floyd PD, Li L, Rubakhin SS, Sweedler JV, Horn CC, Kupfermann I, Alexeeva VY, Ellis TA, Dembrow NC, Weiss KR, Vilim FS. Insulin prohormone processing, distribution, and relation to metabolism in Aplysia californica. J Neurosci. 1999, 19:7732-7741.

Horn CC, Benjamin PR, Weiss KR, Kupfermann I. Decrement of the response of a serotonergic modulatory neuron (the MCC) in Aplysia, during repeated presentation of appetitive (food) stimuli. Neurosci Lett. 1999, 267:161-164.

Horn CC, Addis A, Friedman MI. Neural substrate for an integrated metabolic control of feeding behavior. Am J Physiol (Reg Comp Integr Physiol). 1999, 276:R113‑R119.

Horn CC, Koester J, Kupfermann I. Evidence that hemolymph glucose in Aplysia californica is regulated but does not affect feeding behavior. Behav Neurosci. 1998, 112:1-8.

Horn CC, Kaplan JM, Grill HJ, Friedman MI. Brain Fos-like immunoreactivity in chronic decerebrate and neurologically intact rats given 2,5-anhydro-D-mannitol. Brain Res. 1998, 801:107-115.

Horn CC, Friedman MI. Metabolic inhibition increases feeding and brain Fos-like immunoreactivity as a function of diet. Am J Physiol (Reg Comp Integr Physiol). 1998, 275:R448-R459.

Horn CC, Friedman MI. Methyl palmoxirate increases eating behavior and brain Fos‑like immunoreactivity in rats. Brain Res. 1998, 781:8-14.

Horn CC, Friedman MI. 2,5-Anhydro-D-mannitol induces Fos-like immunoreactivity hindbrain and forebrain: relationship to eating behavior. Brain Res. 1998, 779:17-25.

Horn CC, Tordoff MG, Friedman MI. Does ingested fat produce satiety? Am J Physiol (Reg Comp Integr Physiol) 1996, 270:R761-R765.

Horn CC, Mitchell JC. Does selective vagotomy affect conditioned flavor-nutrient preferences in rats? Physiol Behav. 1996, 59:33-38.

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